Siegmund Oppenheimer was the second of four children born to Berta and Josef Oppenheimer. The family lived in Lower Franconia, where his parents ran a flour and grain business. The family practised traditional Judaism and the children were raised religiously. As the second-born child, Siegmund Oppenheimer would not be joining his parents' business, so after completing a commercial apprenticeship, he travelled to Argentina. From 1929, he lived in Munich, and from 1932 at Zweigstraße 6, working as a sales representative.
Just a few weeks after the National Socialists came to power, his older brother Justin was arrested at the end of April 1933 and sent to the Dachau concentration camp. His cousin Benno from Kitzingen was also deported to the Dachau concentration camp. On 3 May 1933, Siegmund Oppenheimer left Germany and went to Spain. A letter he wrote to his mother in April 1936 contained photos showing him happily in Galicia, where he was employed by the Ourense company.
In the summer of 1936, fascist generals staged a military coup in Spain. Franco's anti-democratic fighters conquered Galicia and started a three-year civil war in Spain. Siegmund Oppenheimer also fought in General Franco's army. He was killed in March 1938 in Alcornocosa on the Córdoba front.